Zirconocene-Mediated Carbonylative Coupling of Grignard Reagents
نویسندگان
چکیده
منابع مشابه
Iron-catalysed, hydride-mediated reductive cross-coupling of vinyl halides and Grignard reagents.
An iron-catalysed, hydride-mediated reductive cross-coupling reaction has been developed for the preparation of alkanes. Using a bench-stable iron(II) pre-catalyst, reductive cross-coupling of vinyl iodides, bromides and chlorides with aryl- and alkyl Grignard reagents successfully gave the products of formal sp(3)-sp(3) cross-coupling reactions.
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The mechanism of the TEMPO mediated oxidative homo-coupling of aryl Grignard reagents is investigated in detail by experimental and computational studies. Experimental data reveal that the nitroxide-mediated homocoupling reaction of aryl Grignard reagents does not occur via free aryl radicals. Evidence for the presence of biaryl radical anions as intermediates in the coupling reaction is provid...
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1,4-Bis[trimethylsilyl(ethynyl)]naphthalene () and 1,4-bis[trimethylsilyl(ethynyl)]anthracene () undergo diastereoselective coupling with Cp2Zr(py)(Me3SiC[triple bond, length as m-dash]CSiMe3) to give trimeric macrocycles in good yield.
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Aliphatic ,w-dibromides can be converted to the corresponding c,w-di—Grignard reagents; for those members carrying less than four carbon atoms between the functions, special procedures are required. The synthesis, structure and applications of the di-Grignard reagents are discussed; particular emphasis is placed on the structures of the corresponding cyclic dialkylmagnesiums, and on the use of ...
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Thermal epimerization is the key to changing the endo-to-exo ratio of the diastereomeric bornyl and fenchyl Grignard reagents from 67:33 to 96:4 and from 20:80 to 80:20, respectively.
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ژورنال
عنوان ژورنال: Angewandte Chemie International Edition
سال: 2016
ISSN: 1433-7851
DOI: 10.1002/anie.201603133